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F. (1991). Early mutation of the neu (erb B-2) gene
during ethylnitrosourea-induced oncogenesis in the rat Schwann cell
lineage. Proc.
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F. (1991). Rat model of the human "Triton" tumor: direct genetic
evidence for the myogenic differentiation capacity of schwannoma cells
using the mutant neu gene as a cell lineage marker. Differentiation
48: 33-42.
- Nikitin, A. Yu., Rajewsky, M. F., and Pozharisski, K. M. (1993). Development
of malignant fibrous histiocytoma induced by 7,12-dimethylbenz [a] anthracene
in the rat: Characterization of early atypical cells. Virchows
Arch. [B].
64:151-159.
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K. M., Winterhager, E., Flesken-Nikitin, A., and Rajewsky, M. F. (1996).
Wild-type neu transgene counteracts mutant homologue in malignant
transformation of rat Schwann cells. Oncogene,
12: 1309-1317.
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- Nikitin, A. Yu., and Lee, W.-H. (1996). Early loss of the retinoblastoma
gene is associated with impaired growth inhibitory innervation during
melanotroph carcinogenesis in Rb+/- mice. Genes
Devel.,
10: 1870-1879.
- Riley, D. J., Nikitin, A. Yu., and Lee, W.-H. (1996). Adenovirus-mediated,
retinoblastoma gene therapy suppresses spontaneous pituitary
melanotroph tumors in Rb+/- mice. Nature
Medicine,
2: 1316-1321.
- Nikitin, A. Yu., Riley, D. J., and Lee, W.-H. (1997). Earlier onset
of melanotroph carcinogenesis in mice with inherited mutant paternal
allele of the retinoblastoma gene. Cancer
Res.,
57:4274-4278.
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L., and Lee W.-H. (1999). RB-mediated suppression of spontaneous multiple
neuroendocrine neoplasia and lung metastases in Rb+/-
mice. Proc.
Natl. Acad. Sci. USA,
96: 3916-3921.
- Utomo, A. R. H., Nikitin, A. Yu., and Lee W.-H. (1999). Temporal,
spatial, and cell type-specific control of Cre-mediated DNA recombination
in transgenic mice. Nature
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17: 1091-1096.
- Nikitin, A. Yu., Riley, D. J., and Lee W.-H. (1999). A paradigm for
cancer treatment using the retinoblastoma gene in a mouse model.
Ann.
NY Acad. Sci.,
886: 12-22.
- Nikitin, A. Yu., Shan, B., Flesken-Nikitin, A., Chang, K.-H., and
Lee, W.-H. (2001). The retinoblastoma gene regulates somatic
growth during mouse development. Cancer
Res.
61: 3110-3118.
- Nikitin, A. Yu., Liu, C.-Y., Flesken-Nikitin, A., Chen, C.-F., Chen,
P.-L., and Lee, W.-H. (2002). Cell lineage-specific effects associated
with multiple deficiencies of tumor susceptibility genes in Msh2-/-Rb+/-
mice. Cancer
Res.,
62: 5134-5138.
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R., Mercer, K. L., Crowley, D., and Jacks, T. (2002). ARF mutation accelerates
pituitary tumor development in Rb+/- mice.
Proc.
Natl. Acad. Sci. USA,
99: 16865-16870.
- Sharp, Z. D., Lee, W.-H., Nikitin, A. Yu., Flesken-Nikitin, A., Ikeno,
Y., Reddick, R., Richardson, A. G., and Nelson J. F (2003). Minimal
effects of dietary restriction on neuroendocrine carcinogenesis in Rb+/-
mice. Carcinogenesis,
24: 179-183.
 |
- Connolly, D. C., Bao, R., Nikitin, A. Yu., Stephens, K. C., Poole,
T., Hua, X., Hanahan, D., Vanderhyden, B., and Hamilton, T. C. (2003).
Female mice chimeric for the expression of the SV40 TAg under control
of the MISIIR promoter develop epithelial ovarian cancer. Cancer
Res.,
63: 1389-1397.
- Zipfel, W. R., Williams, R. M., Christie, R., Nikitin, A. Yu., Hyman,
B. T., and Webb, W. W. (2003). Live tissue intrinsic emission microscopy
using multiphoton-excited fluorescence and second harmonic generation.
Proc.
Natl. Acad. Sci. USA,
100: 7075-7080.
 |
- Flesken-Nikitin, A., Choi, K.-C., Eng, J. P., Shmidt, E. N. and Nikitin,
A. Yu. (2003). Induction of carcinogenesis by concurrent inactivation
of p53 and Rb1 in the mouse ovarian surface epithelium.
Cancer
Res.,
63: 3459-3463.
- Manor, D., Shmidt, E. N., Budhu, A., Flesken-Nikitin, A., Zgola, M.,
Page, R., Nikitin, A. Yu., and Noy, N. (2003). Suppression of mammary
tumor growth by cellular retinoic acid binding protein-II. Cancer
Res.,
63: 4426-4433.
- Hamilton, T. C., Connolly, D. C., Nikitin A. Yu., Garson, K., and
Vanderhyden, B. C. (2003) Translational research in ovarian cancer:
a must. Int.
J. Gynecol. Cancer,
2003 13 (Suppl 2): 220-230.
- Shmidt, E. N., and Nikitin, A. Yu. (2004). Pathology of mouse models
of human lung cancer. Comp.
Medicine, 54:
23-26.
- Nikitin, A. Yu. , Connolly, D. C., and Hamilton, T. C. (2004). Pathology
of ovarian neoplasms in genetically modified mice. Comp.
Medicine,
54: 26-28.
 |
- Nikitin, A. Yu. , Alcaraz, A., Anver, M., Bronson, R. T., Cardiff,
R. D., Dixon, D., Fraire, A. E., Gabrielson, E. W., Gunning, W. T.,
Haines, D. C., Kaufman, M. H., Linnoila, I., Maronpot, R. R., Rabson,
A. S., Reddick, R. L., Rehm, S., Rozengurt, N., Schuller, H. M., Shmidt,
E. N., Travis, W. D., Ward, J. M., and Jacks, T. (2004). Classification
of proliferative pulmonary lesions of the mouse: Recommendations of
the Mouse Models of Human Cancers Consortium. Cancer
Res.,
64: 2307-2316.
- Lin, S.-C. J, Lee, K.-F., Nikitin, A. Yu. , Hilsenbeck, S. G., Cardiff,
R. D., Li, A. Kang, K.-W., Frank, S. A., Lee, W.-H., and Lee E. Y.-H.
(2004). Somatic mutation of p53 leads to estrogen receptor
a-positive and -negative mouse mammary tumors with high frequency of
metastasis. Cancer
Res. 64,
3525-3532.
- Kurie, J. M., Minoo, P., Hecht, S.S., Nikitin, A. Yu. , and DeMayo,
F.J. (2004). Lung cancer. In: Ed. Holland, E. C. Mouse Models of Human
Cancer. Wiley-Liss. New Jersey. p. 83-102.
- Flesken-Nikitin, A., Williams, R. M., Zipfel, W. R., Webb, W.W. and
Nikitin, A. Yu. (2005). Use of multiphoton imaging for studying cell
migration in the mouse. In: Ed. Guan, J.-L. Methods in Molecular Biology,
vol. 294: Cell Migration: Developmental Methods and Protocols. Humana
Press Inc., Totowa , NJ . p.
335 - 344.
- Zhou, Z., Flesken-Nikitin, A., Levine, C. G., Shmidt, E. N., Eng,
J. P., Nikitina, E. Yu., Spencer, D. M., and Nikitin, A. Yu. (2005).
Suppression of melanotroph carcinogenesis leads to accelerated progression
of pituitary anterior lobe tumors and medullary thyroid carcinomas in
Rb+/- mice. Cancer
Res. 65:787-796.
- Nikitin, A. Yu., and Hamilton, T. C. (2005). Modeling ovarian cancer
in the mouse. In: Ed. Mohan, R.M. Research Advances in Cancer. Global
Research Network, Kerala, 49-59.
- Kichina, J. V., Zeremski, M., Aris, L., Gurova, K. V., Walker, E., Franks, R., Nikitin, A. Yu. Kiyokawa, H., and Gudkov, A. V. (2006). Targeted disruption of the mouse ing1 locus results in reduced body size, hypersensitivity to radiation and elevated incidence of lymphomas. Oncogene 25:857-866.
- Daikoku, T., Tranguch, S., Trofimova, I. N., Dinulescu, D. M., Jacks,
T., Nikitin, A. Yu., Connolly, D. C., and Dey, S. K. (2006). Cyclooxygenase-1
is overexpressed in multiple genetically engineered mouse models of
epithelial ovarian cancer. Cancer Res.66:2527-2531.
- Zhou, Z., Flesken-Nikitin, A., Corney, D. C., Wang, W., Goodrich, D. W., Roy-Burman, P. and Nikitin, A. Yu. (2006). Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer. Cancer Res. 66:7889-7898.
- Cardiff, R. D., Anver, M. R., Boivin, G. P., Bosenberg, M. W., Maronpot, R. R., Molinolo, A. A., Nikitin, A. Yu., Rehg, J. E., Thomas, G. V., Russell, R. G., and Ward, J. M. (2006). Precancer in mice: Animal models used to understand, prevent, and treat human precancers. Tox. Pathology. 34:699-707, 2006.
- Sundberg, J. P., Hackman, R. C., HogenEsch, H., Nikitin, A. Yu., and Ward, J. M. (2007). Training mouse pathologists: Five years of pathology of mouse models of human disease workshops. Tox. Pathology. 35:699-707.
- Nikitin, A. Yu., Matoso, A., and Roy-Burman, P. (2007). Prostate stem cells and cancer. Histol. Histopathol. 22: 1043-1049.
 |
- Zhou, Z., Flesken-Nikitin, A. and Nikitin, A. Yu. (2007). Prostate cancer associated with p53 and Rb deficiency arises from the stem/progenitor cell-enriched proximal region of prostatic ducts. Cancer Res. 67:5683-5690.
- Barthold, S. W., Borowsky, A. D., Brayton, C., Bronson, R., Cardiff, R. D., Griffey, S. M., Ince, T. A., Nikitin, A. Yu., Sundberg, J., Valli, V. E., and Ward, J. M. (2007). From whence will they come? – A perspective on the acute shortage of pathologists in biomedical research. J. Vet. Diagnostic Invest. 19:455-456.
- Liao, C.-P., Zhong, C., Saribekyan, G., Bading, J., Park, R., Conti, P. S., Moats, R., Berns, A., Shi, W., Zhou, Z., Nikitin, A. Yu., and Roy-Burman, P. (2007). Mouse models of prostate adenocarcinoma with capacity for monitoring spontaneous carcinogenesis by bioluminescence or fluorescence. Cancer Res. 67:7055-7546.
- Corney, D. C., Flesken-Nikitin, A., Godwin, A. K., Wang, W. and Nikitin, A. Yu. (2007). MicroRNA-34b and -34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res. 67:8433-8438.
- Flesken-Nikitin, A., Toshkov, I.A., Nascar, J., Tyner, K. M., Williams, R. M., Zipfel, W. R., Giannelis, E., and Nikitin, A. Yu. (2007). Toxicity and biomedical imaging of layered nanohybrids in the mouse. Tox. Pathology 35: 804-810.
- Choi, J., Burns, A. A., Williams, R. M., Zhou, Z., Flesken-Nikitin, A., Zipfel, R. W., Wiesner, U., and Nikitin, A. Yu. (2007). Core-shell silica nanoparticles as fluorescent biological labels for nanomedicine applications. J. Biomed. Optics 12: 064007.
- Matoso, A., Zhou, Z, Hayama, R., Flesken-Nikitin, A., and Nikitin, A. Yu. (2008). Cell lineage-specific genetic interactions between Men1 and Rb in neuroendocrine neoplasia. Carcinogenesis 29:620-628.
- Xu, X., Page, J.L., Surtees, J.A., Liu, H., Lagedrost, S., Lu, Y., Bronson, R., Alani, E., Nikitin, A. Yu., and Weiss, R.S. (2008) Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms. Cancer Res. 68:2652-2660.
- Antoch, M. P., Gorbacheva, V. Y., Vykhovanets, O., Toshkov, I. A., Kondratov, R. V., Kondratova, A. A., Lee, C., and Nikitin, A. Yu. (2008). Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis. Cell Cycle 7: 1197-1204.
- Vias, M., Massie, C., E., East, P., Scott, H., Warren, A., Zhou, Z., Nikitin, A. Yu., Neal, D.E. and Mills, I. G. (2008). Pro-neural transcription factors as cancer markers. BMC Medical Genomics 2008, 1:17.
- Schug, T. T., Berry, D. C., Toshkov, I. A., Cheng, L., Nikitin, A. Yu., and Noy, N. (2008). Overcoming retinoic acid-resistance of mammary carcinomas by diverting retinoic acid from PPARβ/δ to RAR. Proc. Natl. Acad. Sci. USA. 105:7546-7551.
- Corney, D. C., Flesken-Nikitin, A., Choi, J. and Nikitin, A. Yu. (2008). Role of p53 and Rb in ovarian cancer. Adv Exp Med Biol. 622:99 -117.
- Corney, D. C., and Nikitin, A. Yu. (2008). MicroRNA and ovarian cancer. Invited review. Histol. Histopathol. 23: 1161-1169.
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