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Dr. Andrew Yen- AY13@cornell.edu
Dr. Andrew Yen, a professor in the Department of Biomedical Sciences, is a member of several graduate fields. His undergraduate and graduate training at Haverford College (BA, physics/mathematics 1969), University of Washington (MS, physics 1970) and Cornell University (PhD, biophysics 1976) led to postdoctoral work at Harvard with A.B. Pardee and subsequent faculty appointments at the Sloan-Kettering Institute for Cancer Research, the University of Iowa, and now Cornell University. Dr. Yen's research has focused on the cellular/molecular control mechanisms regulating cell growth and differentiation which may be pathologically aberrant in cancer. His work has been supported by the National Institutes of Health, The American Institute for Cancer Research, The Council for Tobacco Research, The Children's Leukemia Research Foundation, The United States Department of Agriculture, and the March of Dimes Foundation. Dr. Yen is Director of Graduate Studies in Environmental Toxicology, Director of the Biomedical Sciences Flow Cytometry Core Laboratory, and Associate Director of the Institute for Comparative Environmental Toxicology.

Students

Johanna Congleton- -Graduate Student jc649@cornell.edu
In the myeloblastic hematological tumor cell line HL-60, all-trans retinoic acid (ATRA) treatment results in the rapid expression of CD38, a 46kD transmembrane glycoprotein with both ectoenzyme activity and involvement in intracellular signaling processes. Specifically, it catalyzes the metabolism of NAD+ to nicotinamide and cADPR, a powerful calcium mobilization regulator. CD38 ligation results in MAP kinase signaling, which is necessary for ATRA-induced differentiation. In addition, activation of CD38 leads to phosphorylation of c-Cbl, a protooncogene involved in tyrosine kinase signaling. This aspect of the transduction cascade is an important component of the differentiation process. Overexpression of both CD38 and c-Cbl in HL-60 cells enhances phagocytic ability and cell cycle arrest. Research goals include to elucidate how CD38 functions in leukemic cell differentiation, site-directed mutagenesis to identify key amino acids involved in differentiation signaling, and downstream cellular events that drive ATRA induction therapy.












PostDoctoral Fellows

Miaoqing Shen- -Post Doctoral Fellow ms543@cornell.edu













Petruta(Rodica P. Bunaciu)- -Post Doctoral Fellow rpb78@cornell.edu

Reiterer G, Bunaciu RP, Smith JL, Yen A. Inhibiting the platelet derived growth factor receptor increases signs of retinoic acid syndrome in myeloid differentiated HL-60 cells. FEBS Lett. 2008 Jun 18.

Bunaciu RP, Tharappel JC, Lehmler HJ, Kania-Korwel I, Robertson LW, Srinivasan C, Spear BT, Glauert HP. The effect of dietary glycine on the hepatic tumor promoting activity of polychlorinated biphenyls (PCBs) in rats. Toxicology. 2007 Oct 8;239(3):147-55. Epub 2007 Jul 7.

Glauert HP, Lu Z, Kumar A, Bunaciu RP, Patel S, Tharappel JC, Stemm DN, Lehmler HJ, Lee EY, Robertson LW, Spear BT. Dietary vitamin E does not inhibit the promotion of liver carcinogenesis by polychlorinated biphenyls in rats. J Nutr. 2005 Feb;135(2):283-6.

Marin DE, Taranu I, Bunaciu RP, Pascale F, Tudor DS, Avram N, Sarca M, Cureu I, Criste RD, Suta V, Oswald IP. Changes in performance, blood parameters, humoral and cellular immune responses in weanling piglets exposed to low doses of aflatoxin. J Anim Sci. 2002 May;80(5):1250-7.












Previous Postdoctoral Fellows!
Dr. Gudrun Reiterer -Post Doctoral Fellow gr63@cornell.edu

  Currently enjoying her new position in sunny California.


Wang L, Reiterer G, Toborek M, Hennig B.
Changing ratios of omega-6 to omega-3 fatty acids can differentially
modulate polychlorinated biphenyl toxicity in endothelial cells.
Chem Biol Interact. 2008 Mar 10;172(1):27-38.

Arzuaga X, Reiterer G, Majkova Z, Kilgore MW, Toborek M, Hennig B.
PPARalpha ligands reduce PCB-induced endothelial activation: possible
interactions in inflammation and atherosclerosis.
Cardiovasc Toxicol. 2007;7(4):264-72

Reiterer G, Yen A.
Platelet-derived growth factor receptor regulates myeloid and monocytic
differentiation of HL-60 cells. Cancer Res. 2007 Aug 15;67(16):7765-72.

Reiterer G, Yen A.
Inhibition of the janus kinase family increases extracellular
signal-regulated kinase 1/2 phosphorylation and causes
endoreduplication.Cancer Res. 2006 Sep 15;66(18):9083-9.

Reiterer G, MacDonald R, Browning JD, Morrow J, Matveev SV, Daugherty A,
Smart E, Toborek M, Hennig B.Zinc deficiency increases plasma lipids and
atherosclerotic markers in LDL-receptor-deficient mice.
J Nutr. 2005 Sep;135(9):2114-8.

Hennig B, Reiterer G, Majkova Z, Oesterling E, Meerarani P, Toborek M.
Modification of environmental toxicity by nutrients: implications in
atherosclerosis.Cardiovasc Toxicol. 2005;5(2):153-60. Review.

Hennig B, Reiterer G, Toborek M, Matveev SV, Daugherty A, Smart E,
Robertson LW. Dietary fat interacts with PCBs to induce changes in
lipid metabolism in mice deficient in low-density lipoprotein receptor.
Environ Health Perspect. 2005 Jan;113(1):83-7.

Reiterer G, Toborek M, Hennig B.
Peroxisome proliferator activated receptors alpha and gamma require zinc
for their anti-inflammatory properties in porcine vascular endothelial cells.
J Nutr. 2004 Jul;134(7):1711-5.

Reiterer G, Toborek M, Hennig B.
Quercetin protects against linoleic acid-induced porcine endothelial cell
dysfunction. J Nutr. 2004 Apr;134(4):771-5.

Meerarani P, Reiterer G, Toborek M, Hennig B.
Zinc modulates PPARgamma signaling and activation of porcine endothelial cells.
J Nutr. 2003 Oct;133(10):3058-64.









Dr. Jiangrong Wong - Scientist jw99@cornell.edu
(607)253-3334

Jianrong Wang, earned his Ph.D. at the Shanghai Institute of Biochemistry Chinese Academy of Sciences. He is a research associate scientist here at Cornell University with Dr. Andrew Yen’s lab in the Department of Biomedical Sciences. His current research interest focuses on retinoic acid receptor dependent signal transduction. Wang J, Yen A. A MAPK-positive feedback mechanism for BLR1 signaling propels retinoic acid-triggered differentiation
and cell cycle arrest. J Biol Chem. 2008 Feb 15;283(7):4375-86. Epub 2007 Nov 15.

Wang J, Yen A.
A novel retinoic acid-responsive element regulates retinoic acid-induced BLR1 expression.
Mol Cell Biol. 2004 Mar;24(6):2423-43.













Former Undergraduate Students<

M. Ariel Kauss- Student mak84@cornell.edu













Mike Asaly- Student mea37@cornell.edu













Vic Gupta- Student vkg3@cornell.edu