Heat Capacity of multicomponent lipid membranes with liquid domains
Sarah L. Veatch and Robert E. W. Hancock

The miscibility transition is easily detected by differential scanning calorimetry (DSC) in multilamellar
vesicles containing the lipids DOPC, DPPC, and cholesterol. A discontinuity in the slope of heat capacity
vs. temperature is present at the miscibility transition and the measured transition temperatures are in
excellent agreement with previous NMR results.DSC is a simple and powerful method for studying
the miscibility transition in unperturbed systems. These findings are applied to membranes containing
the host defense peptides Indolicidin and LL-37 and both peptides raise transition temperatures in
model membrane systems.